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Prerequisites

Before you start, make sure you:
1

Install the libSQL dialect

pip install sqlalchemy-libsql python-dotenv
2

Retrieve database credentials

Get the database URL:
turso db show --url <database-name>
Get the database authentication token:
turso db tokens create <database-name>
Assign credentials to the environment variables inside .env.
TURSO_DATABASE_URL=
TURSO_AUTH_TOKEN=
3

Create database models

models.py
from sqlalchemy import String
from sqlalchemy.orm import DeclarativeBase
from sqlalchemy.orm import Mapped
from sqlalchemy.orm import mapped_column

class Base(DeclarativeBase):
    pass

class Item(Base):
    __tablename__ = "items"
    id: Mapped[str] = mapped_column(primary_key=True)
    foo: Mapped[str] = mapped_column(String(255))
    bar: Mapped[str] = mapped_column(String(100))
    def __repr__(self) -> str:
        return f"Item(id={self.id!r}, foo={self.foo!r}, bar={self.bar!r})"
4

Query

from dotenv import load_dotenv
from sqlalchemy import create_engine
from sqlalchemy.orm import Session
from sqlalchemy import select
from models import Item

load_dotenv()

# Get environment variables
TURSO_DATABASE_URL = os.environ.get("TURSO_DATABASE_URL")
TURSO_AUTH_TOKEN = os.environ.get("TURSO_AUTH_TOKEN")

# construct special SQLAlchemy URL
dbUrl = f"sqlite+{TURSO_DATABASE_URL}/?authToken={TURSO_AUTH_TOKEN}&secure=true"

engine = create_engine(dbUrl, connect_args={'check_same_thread': False}, echo=True)

@app.route("/", methods=(["GET"]))
def home():
    session = Session(engine)

    # get & print items
    stmt = select(Item)

    for item in session.scalars(stmt):
        print(item)

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Examples

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See the full source code